Therefore, we Ubc Library Thesis Dissertation recommend you professional essay tutoring. The expert essay tutors at Nascent Minds will elaborate every single detail to you. They will teach you how to write precisely. We Ubc Library Thesis Dissertation are offering quick essay tutoring services round the clock. Only premium essay tutoring can help you in attaining desired results/10() This written thesis supports the MFA exhibition, Circle. In both thesis and exhibition, I articulate that the act of speaking language creates connection for both the speaker and the listener to the history of knowledge and ideas within its specific community of origin. The spok Learning, knowledge, research, insight: welcome to the world of UBC Library, the second-largest academic research library in Canada. Examining impact of interleukin-1 receptor antagonist on fluoxetine efficacy in a preclinical rodent model of postpartum depression - UBC Library Open Collections
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Depression is the leading cause of disability worldwide, where women are twice as likely to be diagnosed than men. Concerningly, selective serotonin reuptake inhibitors SSRIsthe first line antidepressant treatment for PND, show decreased efficacy in treating postpartum depression symptoms compared to antepartum depression symptoms.
Previous research using an animal model of de novo postpartum depression indicates that SSRI inefficacy may be related to increased levels of the proinflammatory cytokine interleukin-1β IL-1β. This thesis aims to further investigate the relationship between inflammation and the postpartum onset of depression, by targeting the IL-1 receptor using an animal model of postpartum depression.
In this model, high corticosterone primary rat glucocorticoid is given to the rat dam postpartum. Anakinra competitively binds to the IL-1 receptor to block IL-1β activity. Our results indicate anakinra treatment has mixed effects on PND endophenotypes, depending on co-treatment with fluoxetine. With and without fluoxetine co-treatment, anakinra decreases microglia in the hippocampus, indicating an overall dampening of neuroinflammation through IL-1 receptors.
Without fluoxetine co-treatment, anakinra decreases maternal care behaviour, whereas anakinra with fluoxetine treatment returned to control levels. Co-treatment of anakinra and fluoxetine resulted in increased active coping behaviours during the Forced Swim Test and increased hippocampal neurogenesis in the ventral dentate gyrus.
Notably, fluoxetine with anakinra co-treatment increased ubc library thesis dissertation hippocampal neurogenesis, ubc library thesis dissertation, while fluoxetine treatment alone was ineffective in these outcome variables. These results suggest a possible therapeutic benefit of anakinra when used as an adjuvant with fluoxetine. Further research is critical to build upon this foundation and continue to explore the connection between neuroinflammation and antidepressant efficacy.
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OpenAthens Login Ubc library thesis dissertation Browser Extension for Access Managing Your Account? My Library Account Login Need Citation Management? Refworks Account Login. JavaScript is disabled: Site features and functionality may be limited. Open Collections. Featured Collection. Abstract Depression is the leading cause of disability worldwide, ubc library thesis dissertation, where women are twice as likely to be diagnosed than men. Item Metadata Title Examining impact of interleukin-1 receptor antagonist on fluoxetine efficacy in a preclinical rodent model of postpartum depression, ubc library thesis dissertation.
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Clark, Emily L. Galea, Liisa ; Oberlander, Tim F. University of British Columbia. Vancouver : University of British Columbia Library. Master of Science - MSc. Medicine, Faculty of.
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Therefore, we Ubc Library Thesis Dissertation recommend you professional essay tutoring. The expert essay tutors at Nascent Minds will elaborate every single detail to you. They will teach you how to write precisely. We Ubc Library Thesis Dissertation are offering quick essay tutoring services round the clock. Only premium essay tutoring can help you in attaining desired results/10() This written thesis supports the MFA exhibition, Circle. In both thesis and exhibition, I articulate that the act of speaking language creates connection for both the speaker and the listener to the history of knowledge and ideas within its specific community of origin. The spok If you have any questions, concerns, or accessibility needs please email blogger.com@blogger.com To keep up-to-date with all of the workshops, consults, and events subscribe to the UBC Library Research Commons monthly newsletter. This event is online. Registrants receive the link 24
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