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a IRCCS SDN, Napoli, Italy. dimarzio unich. d CEINGE-Biotecnologie Avanzate S. Unraveling the proteins interacting with nanoparticles NPs in biological fluids, such as blood, is pivotal to rationally design NPs for drug delivery. The protein corona PrCdissertation on niosomes, formed on the NP surface, represents an interface between biological components and NPs, dictating their pharmacokinetics and biodistribution.
PrC composition depends on biological environments around NPs and on their intrinsic physicochemical properties. PrC composition and relative protein abundance for all designed NIOs were evaluated ex vivo in human plasma HP by quantitative label-free proteomics. We studied the correlation of the relative protein abundance in the corona with cellular uptake of the PrC-NIOs in healthy and cancer human cell lines. Our results highlight the effects of polysorbates on nano-bio interactions to identify a protein pattern most properly aimed to drive the NIO targeting in vivoand assess the best conditions of PrC-NIO NP uptake into the cells.
This study dissected the biological identity in HP of polysorbate-NIOs, thus contributing to shorten their passage from preclinical to clinical studies and to lay the foundations for a personalized PrC. Imperlini, C. Celia, A. Cevenini, A, dissertation on niosomes. Mandola, M. Raia, dissertation on niosomes, M. Fresta, S. Orrù, L. Di Marzio and F. Salvatore, Nanoscaledissertation on niosomes,13DOI: This article is licensed under a Creative Commons Attribution-NonCommercial 3.
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You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page. Issue 10, From the journal: Nanoscale. it d CEINGE-Biotecnologie Avanzate S. This article is part of the themed collection: Recent Open Access Articles. This article is Open Access. Please wait while we load your content Something went wrong. Try again? Cited by. Download options Please wait Supplementary information PDF K. Article type Paper, dissertation on niosomes.
Submitted 09 အောက် Accepted 31 ဒီ First published 05 မတ် Download Citation. Nanoscale, 13BibTex EndNote MEDLINE ProCite ReferenceManager RefWorks RIS.
Request permissions. Nano-bio interface between human plasma and niosomes with different formulations indicates protein corona patterns for nanoparticle cell targeting and uptake E, dissertation on niosomes. Social activity. Search articles by author Esther Imperlini. Christian Celia. Armando Cevenini. Annalisa Mandola. Maddalena Raia. Massimo Fresta. Stefania Orrù. Luisa Di Marzio. Francesco Salvatore.
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